Sebaceous skin lesions as clues to hereditary non-polyposis colorectal cancer.
نویسندگان
چکیده
Cutaneous lesions consonant with Muir-Torre syndrome strongly suggest hereditary non-polyposis colorectal cancer (HNPCC). Ponti et al. discuss the importance of combining molecular genetic features of the sebaceous neoplasms, including microsatellite instability and immunohistochemistry, with family history, to determine the likelihood of HNPCC. Proof of diagnosis is identification of one of the mismatch repair germline mutations.
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عنوان ژورنال:
- The Journal of investigative dermatology
دوره 126 10 شماره
صفحات -
تاریخ انتشار 2006